A | B | |
---|---|---|
1
|
Test Code: 1460 | Valproic Acid |
2
|
Performing Lab: | SMA Specialty Medical Lab |
3
|
Clinical Significance: | Valproic acid is used as an anticonvulsant to treat certain types of seizures, to prevent migraine headaches and to treat various psychiatric illnesses such as bipolar disorder and aggression. Drugs that compete for protein-binding sites with valproic acid can increase the concentration of valproic acid. Therapeutic drug monitoring is useful to optimize dose. Measurement of the free concentration is useful if toxicity is suspected. |
4
|
Reference Ranges: | 50 – 100 mg/L |
5
|
Critical Value: | >120 mg/L |
6
|
Preferred Specimen: | Serum collected in a Red -Top Tube (no gel) |
7
|
Alternate Specimens: | lithium heparin (green-top) |
8
|
Minimum Volume: | 1 mL |
9
|
Specimen Container: | Transfer tube containing separated serum from Red-top tube or plasma from Green-top tube |
10
|
Collection: | Do not use gel barrier tubes. Centrifuge and immediately separate serum or plasma specimens from the cells into clean transport tube. Because the concentration of valproic acid fluctuates considerably depending on the time from last dose, interpretation of the clinical significance of the valproic acid concentration must take into consideration the timing of the blood specimen. Oral: peak: one to four hours after dose (influenced by meals); trough: immediately prior to next dose (possibly more useful than peak values). |
11
|
Transport Temperature: | Refrigerated |
12
|
Specimen Stability: | Refrigerated – 7 days |
13
|
||
14
|
Causes for Rejection | Serum/Plasma not separated from the red cells. Serum-Separator tube; Improper labeling; hemolyzed sample; grossly lipemic sample. |
15
|
Methodology: | Turbidimetric |
16
|
Setup Days: | Monday – Saturday |
17
|
Setup Times: | Every Shift |
18
|
Turnaround: | 24 Hours |
19
|
CPT Code(s): | 80164 |
20
|
(The CPT codes provided are based on AMA guidelines and are for informational purposes only. CPT coding is the sole responsibility of the billing party. Please direct any questions regarding coding to the payer being billed.) | |
21
|
Instrument | SIEMENS Atellica CH |
-
Lab Tests
- 6-AM (Heroin Metabolite)
- AFP
- Albumin
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- Alcohol Biomarkers, EIA
- Alkaline Phosphatase (ALP)
- Allergy Food Panel
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- Creatinine, 24-hour urine
- Creatinine, Random Urine
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- Cytomegalovirus (CMV) IgG Abs
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- D,L-Methamphetamine
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- Digoxin
- Drug Screen 11 (1116B)
- Drug Screen 11 (1120)
- Drug Screen 11 (1189)
- Drug Screen 11 (1365)
- Drug Screen 11 (1372)
- Drug Screen 11 with conf.
- Drug Screen 13 (1116)
- Drug Screen 13 with conf.
- Drug Screen 14 with conf.
- Drug screen 16
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- Drug Screen 18 with conf
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- Drug Screen 3
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- Drug Screen 8
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- Drug Screen 9 (512)
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- Drug Screen-13 with conf
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- Drugs Screen 13 (1366)
- EBV Panel
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- Electrolyte Panel
- ESR
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- H.PILORY
- HCG, TOTAL
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- Hepatitis A Ab Total
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- Hepatitis Bs Ag
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- Hepatitis Panel
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- HISTOLOGY WORKUP
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- Lyme Screen wreflex to WB
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- MEPERIDINE
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- Occult Blood
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- Protein Tota, 24-hour urine
- Protein Total
- PSA (total)
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- PT INR
- PTH, 1-84
- PTT(activated)
- Renal Function Panel
- Respiratory Panel 30
- Respiratory Profile, PCR
- Reticulocyte Count
- Reverse T3
- Rheumatoid Factor
- RPR
- Rubella IgG
- SARS-CoV-2 IgG Antibodies
- SARS-CoV-2 IgM Antibodies
- SHBG
- Sodium
- Specimen Validity Test
- Sputum Culture
- T3 Total
- T3 Uptake
- T3, FREE
- T4 Free
- T4 Total
- TBG
- TCA
- Testosterone, Free
- Testosterone, Total
- THC-COOH
- THINPREP
- Throat Culture
- Thyroglobulin IgG Ab
- Thyroid Panel
- Thyroid Stimulating Immunoglobulins (TSI)
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- Toxicology Oral Fluid
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- Trace Elements (Rendom Urine)
- Trace Elements (Whole Blood)
- Tramadol
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- Tryglicerides
- TSH
- TV, NAA
- Uric Acid
- Uric Acid, 24-Hour Urine
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- Urinalysis Complete
- Urine Culture Comprehensive
- Urine Culture Routine
- Valproic Acid
- Varicella IgG
- Vitamin A
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- Vitamin B5
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- Vitamin D 1,25 OH
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- Wound Culture